Thomas Wısnıewskı

Integration of Neuroimaging and Histopathology in a Squirrel Monkey Model of Spontaneous Cerebral Amyloid Angiopathy and Amyloid-Related Imaging Abnormalities

This study uses MRI and histopathology in squirrel monkeys to link R2* changes with CAA severity and ARIA-related tissue injury, supporting early detection and treatment strategies.

Semaphorin 3G (SEMA3G) is a highly selective marker of cerebral amyloid angiopathy

The paper identifies SEMA3G as a specific marker for cerebral amyloid angiopathy (CAA) through analysis of human brain tissue and demonstrates its interaction with specific amyloid beta variants.

Population-scale subcellular proteomics reveals intracellular remodelling across the Alzheimer's disease-resilience spectrum

The paper uses subcellular proteomics to identify disease-associated protein localization shifts in Alzheimer's disease across the resilience spectrum, revealing insights beyond abundance-based proteomics.

Short T1 Fraction as a Marker of Myelin Content: Evidence from Postmortem MRI and Histology

This study investigates the short-T1 fraction as a biomarker of myelin content using postmortem MRI and histology, showing strong correlations with myelin water imaging and histological markers.

Non-invasive MRI mapping of tissue-CSF water exchange reveals glymphatic fluid movement in live human cortex

This study uses MRI to show glymphatic fluid movement in live human cortex, finding reduced exchange in Alzheimer's disease.

FDA-approved carbonic anhydrase inhibitors reduce Amyloid beta pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness

This study tests FDA-approved carbonic anhydrase inhibitors in a transgenic AD model, finding they reduce amyloid beta pathology and improve cognition by enhancing cerebrovascular health and glial function.

Compilation of all known protein changes in the human Alzheimer's disease brain

The paper compiles and analyzes proteomic data from 38 Alzheimer's disease studies to create a database of protein changes in human brain tissue across disease stages and regions, revealing patterns of protein dysfunction.

Proteomic Differences in the Hippocampus and Cortex of Epilepsy Brain Tissue

The paper identifies proteomic differences in epilepsy brain tissue, highlighting altered protein networks in hippocampus, cortex, and dentate gyrus, with GNB1 as a key decreased protein.

Proteomic and Transcriptomic Analyses of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Cases

The paper compares proteomic and transcriptomic profiles of hippocampus and cortex in SUDEP and high-risk SUDEP cases, finding no proteomic differences but 55 differentially expressed genes in hippocampus.