NeurosciencebioRxivPreprint
iPSC Motor Neurons with Familial ALS Mutations Capture Gene Expression Changes in Postmortem Sporadic ALS Motor Neurons
Aaron Held, Michelle J. Adler, Christine Marques…·Brian J. Wainger
The paper shows iPSC-derived spinal motor neurons with familial ALS mutations capture gene expression changes seen in postmortem sporadic ALS motor neurons, particularly in TDP-43-related splicing dysregulation.
DOI 10.1101/2022.10.25.513780