Aaron Held

The paper shows statins and mevalonate pathway inhibition increase STMN2 and ATF3, promoting neuronal regeneration in neurodegenerative disease.

The paper identifies RIG-I-mediated innate immune activation in FUS-ALS spinal motor neurons due to mitochondrial dsRNA accumulation, which can be targeted by JAK-STAT inhibition, offering potential biomarker-driven treatment options.

This study identifies GSDME as a mediator of mitochondrial damage and axon loss in neurodegenerative diseases, showing its role in ALS and FTD models.

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

The paper shows iPSC-derived spinal motor neurons with familial ALS mutations capture gene expression changes seen in postmortem sporadic ALS motor neurons, particularly in TDP-43-related splicing dysregulation.

The paper develops a cultured sensorimotor organoid model that forms functional neuromuscular junctions and uses it to study ALS subgroups.

This study identifies two BMP ligands, Gbb and Dpp, that mediate bidirectional glia-neuron signaling to regulate synaptic growth in Drosophila.

The paper identifies sensory feedback defects as an early event in ALS motor dysfunction in a Drosophila model and shows BMP signaling in proprioceptors can alleviate motor deficits.