Author

Ana Rita Agra de Almeida Quadros

Broad InstituteORCID 0000-0002-6909-2420Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aaron HeldiD· 2 shared Brian J. WaingeriD· 2 shared Clotilde Lagier‐TourenneiD· 2 shared I. Sandra NdayambajeiD· 2 shared Michael Emmerson WardiD· 2 shared Amey S. Kavuturu· 1 shared Ayub BoulosiD· 1 shared Benjamin P. KleinstiveriD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Aaron HeldORCID

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2 papers

Recent·Most cited

Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative program

Matthew Nolan, Sandeep Aryal, I. Sandra Ndayambaje, Maize Cao, Peyton Lee, Moriah J. Hovde, Shuqi Yun, Josette J Wlaschin, Aaron Held, Hortense D. A. M. Beaussant, Benjamin Wymann, Chao-Zong Lee, Su Min Lim, Xin Jiang, Nandini Ramesh, , Clotilde Lagier‐Tourenne

The paper shows statins and mevalonate pathway inhibition increase STMN2 and ATF3, promoting neuronal regeneration in neurodegenerative disease.

bioRxiv · Feb 24, 2026 · PreprintNeuroscience

iPSC Motor Neurons with Familial ALS Mutations Capture Gene Expression Changes in Postmortem Sporadic ALS Motor Neurons

Aaron Held, Michelle J. Adler, Christine Marques, Amey S. Kavuturu, Ana Rita Agra de Almeida Quadros, I. Sandra Ndayambaje, Erika Lara, Michael Emmerson Ward, Clotilde Lagier‐Tourenne, Brian J. Wainger

The paper shows iPSC-derived spinal motor neurons with familial ALS mutations capture gene expression changes seen in postmortem sporadic ALS motor neurons, particularly in TDP-43-related splicing dysregulation.

bioRxiv · Oct 25, 2022 · PreprintNeuroscience