DNA methylation shapes the Polycomb landscape during the exit from naïve pluripotency
Julien Richard Albert, Teresa Urli, Ana Monteagudo, Anna Le Breton, Amina Sultanova, Angélique David, Margherita Scarpa, Mathieu Schulz, Max Greenberg
This study investigates how DNA methylation influences the Polycomb landscape during the exit from naïve pluripotency, finding that 5mC can antagonize H3K27me3 and activate genes in differentiated cells.
Nature Structural & Molecular Biology · Oct 24, 2024Peer-reviewedMolecular Biology