Julien Richard Albert

Dual profiling of DNA modifications with enhancer features during the exit of naive pluripotency

The paper uses Methyl-ATAC and Methyl-CUT&Tag to study 5mC and 5hmC dynamics during mESC differentiation, revealing their role in enhancer regulation.

Dual PAX3/7 transcriptional activities spatially encode spinal cell fates through distinct gene networks

The paper shows PAX3/7 transcription factors use distinct gene networks to spatially control spinal cell fates through repression and activation mechanisms.

DNA methylation shapes the Polycomb landscape during the exit from naïve pluripotency

This study investigates how DNA methylation influences the Polycomb landscape during the exit from naïve pluripotency, finding that 5mC can antagonize H3K27me3 and activate genes in differentiated cells.

The embryonic DNA methylation program modulates the cis-regulatory landscape via CTCF antagonism

This study shows that DNA methylation affects CTCF binding and 3D chromatin structure during mouse embryonic differentiation.

A genome-wide knock-out screen for actors of epigenetic silencing reveals new regulators of germline genes and 2-cell like cell state

The paper identifies new regulators of germline genes and 2-cell like cell state through a genome-wide CRISPR knock-out screen in mouse ES cells.

Conservation and divergence of canonical and non-canonical imprinting in murids

The paper identifies imprinted genes in rat tissues, finds conservation of canonical imprints in embryos but divergence in extra-embryonic tissues, and discovers novel non-canonical imprints.

Maternal DNMT3A-dependent de novo methylation of the zygotic paternal genome inhibits gene expression in the early embryo

The paper shows maternal DNMT3A promotes de novo methylation on the paternal genome in early embryos, which suppresses gene expression.