A multiplex, prime editing framework for identifying drug resistance variants at scale
Florence M. Chardon, Chase C. Suiter, Riza M. Daza, Nahum T. Smith, Phoebe C. R. Parrish, Troy A. McDiarmid, Jean‐Benoît Lalanne, Beth Martin, Diego Calderon, Amira Ellison, Alice H. Berger, Jay Shendure, Lea M. Starita
This paper introduces prime-SGE, a prime editing framework for assessing drug resistance variants across multiple oncogenes in a single experiment.
bioRxiv · Jul 27, 2023 · PreprintGenomics