Neuropathic pain drives time-dependent reorganization of naturalistic movement and corticostriatal circuits
Arlene J. George, Ivan Linares-García, Alex J. Yonk, Xinyi Christine Zhang, Justin Burdge, Ammar Danish, Mark A. Gradwell, Victoria E. Abraira, David J. Margolis
This study identifies time-dependent changes in corticostriatal circuits and movement patterns in a chronic pain model, highlighting a critical 3-week transition phase for therapeutic intervention.
bioRxiv · Oct 7, 2025 · PreprintNeuroscience