Mark A. Gradwell

This study shows that Sall3 is essential for forming GABApre synapses on Ia afferents, and its loss disrupts motor behavior by impairing presynaptic inhibition.

This study identifies spinal oxytocin circuits as a conserved mechanism through which affiliative touch reduces pain and enhances well-being in mice and humans.

This study identifies time-dependent changes in corticostriatal circuits and movement patterns in a chronic pain model, highlighting a critical 3-week transition phase for therapeutic intervention.

The paper develops a closed-loop optogenetic system using DeepLabCut-Live to manipulate sensory neuron activity during specific phases of locomotion in mice, revealing context-specific behavioral responses.

This study identifies the role of the gracile nucleus in mediating tactile sensitivity and mechanical allodynia during neuropathic pain in mice.

This study investigates the role of posterior medial thalamus (POm) in striatal circuitry and choice behavior, finding that POm-striatal projections influence reaction times and learning through arousal-related signals.

This study identifies glycinergic inhibitory neurons in the spinal cord deep dorsal horn that integrate sensory inputs and modulate motor output during locomotion.

The paper identifies Mrgprb4-lineage neurons as critical for sexual receptivity and dopaminergic reward from social touch in mice.

The paper identifies that excitatory and inhibitory parvalbumin interneurons in the spinal dorsal horn form distinct circuits and that excitatory interneurons contribute to mechanical hypersensitivity under pathological conditions.

This study identifies calretinin-positive neurons in the spinal cord dorsal horn as part of an excitatory network that amplifies pain signals and is a potential target for analgesic therapies.