IRF7 deficiency increases disease severity independently of TLR7 recognition in Influenza A infection in mice
Ana Karina Nisperuza Vidal, Chenxiao Wang, Michaela J. Allen, Xiaofeng Ding, Jefferson Fernandes Evangelista, Yilin Chen, M Khatun, Amrita Kumar, Calder R. Ellsworth, Mohammad Islamuddin, Robert V. Blair, Suryaprakash R. Sambhara, Jay K. Kolls, Derek A. Pociask, Xuebin Qin
This study shows that IRF7 deficiency worsens influenza A disease in mice, independent of TLR7, by impairing early interferon responses and adaptive immunity.
bioRxiv · May 26, 2026 · PreprintImmunology