TREM2 drives monocyte-derived macrophage responses to Cryptococcus neoformans
Adiza Abass, Alison Ricafrente, Apurwa Trivedi, Amy Vichaidit, Aelita Arshakyan, Sreemoyee Acharya, Lena J. Heung
This study identifies TREM2 as a DAP12-associated receptor that inhibits macrophage antifungal responses to Cryptococcus neoformans by reducing fungal uptake and M1 polarization.
bioRxiv · Jun 11, 2026 · PreprintImmunology