BRD4, Mediator, and Pol II form heterogeneous condensates with distinct transcriptional and acetylation-dependent states
Samuel Shoup, Alina Schaaf, Kathrin Hertäg, Amy-Sue Sattler, Márton Gelléri, Fridolin Kielisch, Thomas Speck, Sandra Schick
The paper quantifies transcriptional condensate states using chemical perturbations and finds BRD4-only condensates that are acetylation-dependent and distinct from canonical transcriptionally engaged condensates.
bioRxiv · Jun 8, 2026 · PreprintCell Biology