Fridolin Kielisch

The paper identifies brain-specific functions of NDD-associated genes by analyzing gene expression and regulatory mechanisms across tissues.

This study identifies Myo6's role in DSB repair by interacting with KU70/80 and VCP, facilitated by F-actin, to extract the KU70/80 complex from chromatin.

The paper quantifies transcriptional condensate states using chemical perturbations and finds BRD4-only condensates that are acetylation-dependent and distinct from canonical transcriptionally engaged condensates.

This study systematically profiles drug responses in BAF complex perturbations, revealing subtype-specific vulnerabilities and resistance patterns to genotoxic and cytotoxic compounds.

The paper shows SNRPN, a paralogue of SNRPB, stabilizes metabolic transcripts and enhances mitochondrial function, revealing a methylation-dependent mechanism for metabolic specialization in mammals.

The paper identifies a novel regulatory mechanism involving proteolytic processing of N-terminal intrinsically disordered regions in C. elegans Argonaute proteins, which controls small RNA selectivity and activity.

This study shows that TDP-43 and Tau directly interact, promoting co-condensation but reducing Tau fibril formation and seeding.

This study shows that maternal Tdrd6a and Tdrd6c are essential for germplasm stability, germ cell specification, and fertility in zebrafish.

This study identifies the roles of argonaute proteins in RNAi inheritance in C. elegans, showing HRDE-1 is required for silencing while WAGO-3 is essential for inheritance.

The paper identifies mutations and RNA-binding proteins affecting CD19 splicing and CART-19 therapy resistance through high-throughput mutagenesis and mathematical modeling.

The paper identifies LOTR-1, a C. elegans protein with LOTUS and Tudor domains, which interacts with ZNFX-1 to regulate small RNA processing in the germline.