Thomas Speck

Kinase-phosphatase cycles drive self-sustained oscillations of protein condensates

This study shows that kinase-phosphatase cycles drive self-sustained oscillations in TDP-43 condensates through differential recruitment and slow redistribution of enzymes.

Active field theory approach to explain size control of transcriptional condensates

The paper uses microscopy and field theory to show transcriptional condensates exhibit size control through non-equilibrium dynamics.

BRD4, Mediator, and Pol II form heterogeneous condensates with distinct transcriptional and acetylation-dependent states

The paper quantifies transcriptional condensate states using chemical perturbations and finds BRD4-only condensates that are acetylation-dependent and distinct from canonical transcriptionally engaged condensates.

Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates

The paper uses molecular simulations to study how phosphorylation by CK1δ affects TDP-43 condensates and aggregation, finding that phosphorylation patterns depend on sequence and charge rather than position.