Targeting a macrophage stemness factor to mitigate diseases post respiratory viral infection
Mohd Arish, Arka Sen Chaudhuri, Janli Tang, Harish Narasimhan, An Fang, Jinyi Tang, Xiaoqin Wei, Chaofan Li, In Su Cheon, Wei Qian, Farha Naz, Gislane Almeida-Santos, Samuel Patrick Young, Tanyalak Parimon, Yun Michael Shim, , Jie Sun
This study identifies TCF4 as a critical regulator of alveolar macrophage stemness and shows that targeting TCF4 can mitigate post-viral lung disease and fibrosis.
bioRxiv · Oct 3, 2025 · PreprintImmunology