Tanyalak Parimon

An evidence-governed agent harness for spatial transcriptomics prioritizes ICAM-1 as a target in lung fibrosis

DeepMAST, an AI system for spatial transcriptomics, identifies ICAM-1 as a therapeutic target in lung fibrosis through evidence-based analysis and validation.

Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung Fibrosis.

This study shows that syndecan-1 promotes AT2 cell senescence in lung fibrosis, contributing to fibrotic remodeling and suggesting it as a therapeutic target.

Targeting a macrophage stemness factor to mitigate diseases post respiratory viral infection

This study identifies TCF4 as a critical regulator of alveolar macrophage stemness and shows that targeting TCF4 can mitigate post-viral lung disease and fibrosis.

Phosphatidylcholine Metabolism Controls Alveolar Progenitor Renewal and Pulmonary Fibrosis

This study identifies LPCAT1 as a critical regulator of AT2 cell renewal and lipid metabolism in IPF, showing that reactivating LPCAT1 can mitigate lung fibrosis.

Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell homeostasis in idiopathic pulmonary fibrosis and reverses pulmonary fibrosis in mice

This study identifies NAMPT as a key regulator of alveolar progenitor cell function in IPF, showing that its activation restores homeostasis and reverses fibrosis in mice.