Author

Yun Michael Shim

University of VirginiaORCID 0000-0002-3780-3371Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 1

Frequent Co-Authors

Eva OtoupalovaiD· 2 shared Jeffrey M. SturekiD· 2 shared Riley T. HannaniD· 2 shared Aditi UpadhyeiD· 1 shared Alexandra KadliD· 1 shared Amr A.E. Atya· 1 shared An Fang· 1 shared Andrew Julio BarrosiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Eva OtoupalovaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

IgA antibodies against oxidation-specific epitopes are generated by double negative B cells and are associated with impaired lung function in fibrotic interstitial lung diseases.

Eva Otoupalova, Riley T. Hannan, Pearl Raichura, Noora Batrash, Paul Dell, Mônica Josiane Rodrigues‐Jesus, Eli R. Zunder, Jeffrey M. Wilson, Judith A. Woodfolk, Justin J. Taylor, Shwu‐Fan Ma, Andrew Julio Barros, Yun Michael Shim, Imre Noth, Catherine A. Bonham, , Jeffrey M. Sturek

This study identifies elevated anti-oxidation-specific epitope (OSE) IgA antibodies in fibrotic interstitial lung diseases (fILD) and links them to impaired lung function and a specific B cell subset.

bioRxiv · Dec 2, 2025 · PreprintImmunology

Targeting a macrophage stemness factor to mitigate diseases post respiratory viral infection

Mohd Arish, Arka Sen Chaudhuri, Janli Tang, Harish Narasimhan, An Fang, Jinyi Tang, Xiaoqin Wei, Chaofan Li, In Su Cheon, Wei Qian, Farha Naz, Gislane Almeida-Santos, Samuel Patrick Young, Tanyalak Parimon, Yun Michael Shim, , Jie Sun

This study identifies TCF4 as a critical regulator of alveolar macrophage stemness and shows that targeting TCF4 can mitigate post-viral lung disease and fibrosis.

bioRxiv · Oct 3, 2025 · PreprintImmunology

A protective role for B-1 cells and oxidation-specific epitope IgM in lung fibrosis

Jeffrey M. Sturek, Riley T. Hannan, Aditi Upadhye, Eva Otoupalova, Edwin T. Faron, Amr A.E. Atya, Cassidy Thomas, Vernerdean Johnson, Andrew Miller, James C. Garmey, Marie D. Burdick, Thomas Harrison Barker, Alexandra Kadl, Yun Michael Shim, Coleen A. McNamara

This study shows B-1 cells and IgMOSE reduce lung fibrosis by modulating CXCR4 and Id3, with sIgM-/- mice showing increased mortality from bleomycin injury.

bioRxiv · Apr 11, 2024 · PreprintImmunology