Aberrant Connectivity Across the Lifespan in a Mouse Model of Alzheimer's disease and Rescue by mGluR5 Modulator Treatment
Francesca Mandino, Xilin Shen, Gabriel Desrosiers-Grégoire, David A. O’Connor, Bandhan Mukherjee, Ashley Owens, An Qu, John A. Onofrey, Xenophon Papademetris, M. Mallar Chakravarty, Stephen M. Strittmatter, Evelyn M. R. Lake
The paper uses fMRI to track functional connectivity changes in a mouse model of Alzheimer's disease over time and shows that mGluR5 modulator treatment reverses these deficits.
bioRxiv · Dec 15, 2023 · PreprintNeuroscience