Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites
Jacqueline M. Tokarew, Daniel N. El Kodsi, Nathalie A. Lengacher, Travis K. Fehr, Angela Nguyen, Bojan Shutinoski, Brian O’Nuallain, Ming Jin, Jasmine M. Khan, Andy Cheuk‐Him Ng, Juan Li, Qiubo Jiang, Mei Zhang, Liqun Wang, Rajib Sengupta, , Michael G. Schlossmacher
This study investigates how parkin's redox state and insolubility in human midbrain relate to oxidative stress and dopamine metabolism, showing that parkin's cysteine modifications affect H2O2 levels and neuroprotection.
Acta Neuropathologica · Mar 10, 2021Peer-reviewedNeuroscience