Eve Chung Tsai

Expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and late postnatal development

The paper investigates the expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and development, finding conserved expression but species- and development-specific localization patterns.

Processing and sectioning of organ donor spinal cord tissue for electrophysiology on acute human spinal cord slices

This paper describes a protocol for preparing viable human spinal cord slices for acute electrophysiological recordings to bridge the translational gap between rodent models and human patients.

Poly-L-Ornithine Coated Plant Scaffolds Support Motor Recovery in Rats after Traumatic Spinal Cord Injury

This study shows that poly-L-ornithine-coated plant scaffolds improve motor recovery and neural repair in rats with spinal cord injury.

Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use

Heterogeneity of synaptic NMDA receptor responses within individual lamina I pain processing neurons across sex in rats and humans

The paper compares NMDA receptor decay kinetics in lamina I pain neurons across sex and species, finding conserved heterogeneity but species-specific differences in subunit contributions.

A Cellular Taxonomy of the Adult Human Spinal Cord

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.

Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain

The paper identifies a sex-specific neuronal mechanism of spinal hyperexcitability in pain models, showing differences in BDNF signaling between male and female rodents and humans.

Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites

This study investigates how parkin's redox state and insolubility in human midbrain relate to oxidative stress and dopamine metabolism, showing that parkin's cysteine modifications affect H2O2 levels and neuroprotection.

Oxidative Modifications of Parkin Underlie its Selective Neuroprotection in Adult Human Brain

This study identifies oxidative modifications of parkin in adult human brain that confer neuroprotection by reducing H2O2, conjugating dopamine radicals, and forming neuromelanin.