Alexandre Prat

This study identifies T-bet+ memory B cells as pathogenic in MS by activating microglia/macrophages via IFN-γ, worsening EAE and demyelination.

The paper introduces RF-PHATE, a supervised data visualization method that integrates expert knowledge to enhance interpretation of complex biological data.

This study identifies gene-environment interactions influencing immune response to SARS-CoV-2 in hospitalized patients using single-cell RNA-sequencing and eQTL analysis.

This study shows fibrinogen has opposing effects on human oligodendrocyte lineage cells depending on their maturation stage, inhibiting early differentiation but enhancing myelination in mature cells.

This study investigates ependymal cilia dysfunction in multiple sclerosis, finding dysregulated ciliary genes and impaired ciliary function in MS patients and animal models.

The paper rebuts claims that astrocyte epigenetic memory is due to immune cell contamination, showing its existence in pure astrocyte cultures and MS samples.

This study monitors beta cell function in vivo over time, showing hyperglycemia disrupts Ca2+ dynamics and hub cells, while GLP1R agonism restores them.

This study identifies a senescent-like phenotype in neurons under inflammation and shows that rejuvenation improves survival in an MS model.

The paper uses multiomic single nucleus RNA/ATAC sequencing to show ependymal cell dysregulation correlates with periventricular pathology in MS and identifies IFNγ as a driver.

The paper identifies four subpopulations of human choroid plexus epithelial cells, including TYRP1-high cells with distinct molecular features related to pigmentation, cell cycling, and stress.

This study shows that senolytic treatment reduces microglia and alleviates EAE symptoms in mice, suggesting senescent glia contribute to neuroinflammation.

This study identifies immune gene expression signatures in neurons from MS patients and EAE mice, revealing shared pathways and potential roles for IRF5 and STAT1 in neuronal inflammation.

This study identifies an epigenetically controlled memory astrocyte subset that exacerbates CNS pathology in EAE and MS by promoting pro-inflammatory responses.

This study creates a cell atlas of the adult human subventricular zone using single-cell transcriptomics, identifying multipotent neural stem cells and their lineage potential.

This study investigates how parkin's redox state and insolubility in human midbrain relate to oxidative stress and dopamine metabolism, showing that parkin's cysteine modifications affect H2O2 levels and neuroprotection.

This study identifies oxidative modifications of parkin in adult human brain that confer neuroprotection by reducing H2O2, conjugating dopamine radicals, and forming neuromelanin.

The paper investigates altered expression and mislocalization of RNA-binding proteins TDP-43 and PTB in multiple sclerosis lesions and cultured oligodendrocytes, linking them to demyelination and neurodegeneration.

This study shows that immunotherapy reduces disability and relapses in relapsing multiple sclerosis over 15 years.

The paper identifies miR-223-3p and miR-27a-3p as upregulated in MS models and shows they protect neurons by downregulating glutamate receptor signaling.