Spatial architecture of CD8+ T cells and DC subsets is critical for the response to immune checkpoint inhibitors in melanoma
Elisa Gobbini, Margaux Hubert, Anne-Claire Doffin, Anais Eberhardt, Leo Hermet, Danlin Li, Pierre Duplouye, Sarah Barrin, Justine Berthet, Valentin Benboubker, Maxime Grimont, Candice Sakref, Jimmy Perrot, Garance Tondeur, Olivier Harou, , Jenny Valladeau-Guilemond
This study examines the spatial organization of dendritic cell (DC) subsets and their interactions with CD8+ T cells in melanoma patients, finding that proximity between cDC1 and CD8+ T cells correlates with response to immune checkpoint inhibitors.
bioRxiv · Feb 6, 2024 · PreprintCancer Biology