A novel mode of communication between blood and the germline for the inheritance of paternal experiences
Gretchen van Steenwyk, Katharina Gapp, Ali Jawaid, Pierre‐Luc Germain, Francesca Manuella, Deepak K. Tanwar, Nicola Zamboni, Niharika Gaur, Anastasiia Efimova, Kristina M. Thumfart, Eric Alexander Miska, Isabelle M. Mansuy
The paper shows that paternal trauma alters blood metabolites and sperm transcriptomes, which can be transmitted to offspring via PPAR-mediated mechanisms.
The EMBO Journal · Oct 9, 2020Peer-reviewedMolecular Biology