Isabelle M. Mansuy

The paper shows that paternal diet affects both paternal and maternal transcriptomes in early embryos through distinct sperm-related mechanisms.

This study shows early-life stress alters the transcriptome and chromatin accessibility of mouse spermatogonial cells, with molecular signatures persisting into adulthood.

The paper shows that stress-induced changes in extracellular vesicles from mice can alter sperm and embryo transcriptomes, leading to metabolic issues in offspring.

NanoTag is an IgG-free method for mapping DNA-protein interactions using a nanobody-Tn5 transposase fusion, showing high correlation with CUT&Tag data in mouse embryonic stem cells.

This study investigates how early postnatal stress affects Sertoli cell function in adult mice, finding persistent impairments in electron transport chain pathways.

Paternal exposure to early life stress alters miRNA cargo in epididymal extracellular vesicles, correlating with changes in target gene expression in sperm and zygotes.

The paper outlines the protocol for the EarlyCause project, which investigates the biological mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity using longitudinal data, animal models, and cellular systems.

The paper shows that paternal trauma alters blood metabolites and sperm transcriptomes, which can be transmitted to offspring via PPAR-mediated mechanisms.

The paper examines chromatin remodeling and gene expression dynamics in mouse spermatogonial cells across postnatal development using RNA-seq and ATAC-seq.

The paper shows that alterations in sperm long RNA contribute to the inheritance of trauma-induced behavioral and metabolic effects.