Katharina Gapp

This study shows that different stress types cause distinct plasma proteomic and metabolic responses in humans, with physical stress having the strongest effect.

The paper predicts transcription factor binding across 43 human cell types using ATAC-seq data and a new platform, revealing promiscuous occupancy and chromatin contacts.

This study investigates how repeated stress affects molecular responses in the mouse hippocampus, finding widespread habituation without new adaptive responses or baseline gene expression changes.

The paper benchmarks methods for identifying differentially-active transcription factors from ATAC-seq data using curated and simulated datasets, identifying three promising approaches.

This paper introduces a novel GR degrader, KH-103, which selectively degrades glucocorticoid receptors and shows improved efficacy over existing inhibitors.

The paper shows acute paternal Dexamethasone exposure alters sperm RNA and offspring metabolism, identifying circRNAs as novel RNA-mediated inheritance candidates.

This study characterizes the molecular changes in the mouse hippocampus during the acute stress response using multiomic profiling and identifies rapid resolution of molecular events within 4 hours.

The paper shows that paternal trauma alters blood metabolites and sperm transcriptomes, which can be transmitted to offspring via PPAR-mediated mechanisms.

This study examines the small RNA profile of house sparrow sperm to explore how paternal age affects offspring fitness, finding no significant differences in miRNA and tRNA fragments between aged and prime sperm.

The paper shows that alterations in sperm long RNA contribute to the inheritance of trauma-induced behavioral and metabolic effects.

SLAM-ITseq enables transcriptome analysis of specific cell types in tissues without prior sorting, providing accurate in vivo transcriptional snapshots.