Eric Alexander Miska

This study shows that MSC-EVs prevent NGF-induced sensory neuron sensitization through miRNA-mediated transcriptional regulation.

This study identifies SET-24, a catalytically inactive SET domain protein in C. elegans, as essential for maintaining transgenerational epigenetic memory through its interaction with HCF-1 and regulation of H3K4me3 levels.

The paper presents a mouse pangenome with 17 strains, resolving structural complexity and improving RNA-Seq analysis by identifying non-reference genes and VNTR polymorphisms.

The paper identifies a compensatory tRNA modification pathway mediated by DUS3L that allows oesophageal cancer cells to resist METTL1 loss, suggesting DUS3L as a biomarker and therapeutic target.

The paper analyzes 1,375 Malawi cichlid genomes to show that sex-linked chromosomal inversions drive adaptive speciation through introgression and selection on neuro-sensory, physiological, and reproductive genes.

The paper identifies recurrent capture of transposable element domains by F-box genes across eukaryotes and shows their functional integration into host regulatory networks.

The paper investigates the dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes, revealing expanded piwil1 genes and divergent piRNA-producing loci.

The paper shows that m6A modification of U6 snRNA by METT-10 is essential for accurate and efficient cis- and trans-splicing in C. elegans pre-mRNAs.

comradesOO is an R package for analyzing RNA structure data from COMRADES experiments, providing tools for processing, clustering, and comparing RNA structures and interactions.

The paper uses a pangenomic approach to analyze Lake Malawi cichlid genomes, revealing extensive structural variation driven by transposable elements.

The paper shows that AMPK regulates small RNA pathways in somatic cells to control germline stem cell quiescence during energy stress in C. elegans.

The paper generates and analyzes genome assemblies for 24 Antarctic notothenioid fish species to study cold adaptations, identifying genomic changes related to antifreeze proteins and haemoglobin loss.

The paper presents a high-quality genome assembly of Rhizophagus irregularis, revealing genomic innovations specific to the Glomeromycotina subphylum.

This study identifies the role of SPT2 in chromatin structure and function across Metazoa, showing its importance in germline development and chromatin accessibility.

The paper identifies mutations in E3 ubiquitin ligases that restore development in SWI/SNF mutants in C. elegans, suggesting potential therapeutic targets for human developmental disorders.

The paper shows that transgenerational gene silencing in C. elegans is maintained by a self-tuning mechanism based on resource competition, leading to long-term memory-like persistence.

The paper investigates epigenetic divergence in two ecomorphs of Astatotilapia calliptera, finding methylome differences linked to ecological adaptation and showing that these differences can be inherited across generations.

The paper identifies G-quadruplex motifs enriched near splice junctions and shows their involvement in alternative splicing in neuronal cells.

This study uses CRISPR/Cas9 to edit the oca2 gene in Astatotilapia calliptera, demonstrating efficient germline transmission and phenotypic effects on melanin synthesis.

TransposonUltimate is a software package for transposon classification, annotation, and detection, outperforming existing methods and providing a unified framework.

This study shows that TUT4/7 regulate miRNA variants in a cell-type-specific manner, affecting cancer cell properties and miRNA-mRNA networks.

The paper examines transcriptional activity and epigenetic regulation of transposable elements in the symbiotic fungus Rhizophagus irregularis, finding evidence of TE activity and epigenomic regulation.

The paper investigates the structural features of the NORAD lncRNA and their role in modulating Pumilio protein activity through RNA structure and interactions.

The paper examines methylome and transcriptome divergence in Lake Malawi cichlid fishes, finding links between epigenetic changes and ecological adaptation.

The paper investigates intergenerational stress adaptations in C. elegans across four stress types, finding conserved physiological responses with trade-offs, but no long-term transgenerational gene expression changes.

The paper shows acute paternal Dexamethasone exposure alters sperm RNA and offspring metabolism, identifying circRNAs as novel RNA-mediated inheritance candidates.

This paper develops methods for delivering macromolecules and expressing exogenous mRNA in plant-parasitic nematodes, advancing functional genetic tools for these pests.

MicroExonator identifies and quantifies microexons across mouse embryonic development, revealing 332 differentially spliced microexons and cell-type specific inclusion in neuronal subpopulations.

This study shows that m5C RNA modification in C. elegans affects translation efficiency and adaptation to heat stress by modulating leucine and proline decoding.

This study maps the RNA-RNA interactome of SARS-CoV-2, revealing long-range interactions and conserved structural elements important for viral replication and translation.