Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes
Chaitra Rao, Daniel T. Cater, Saptarshi Roy, Zhiwei Xu, Andre G. De Oliveira, Carmella Evans‐Molina, Jon D. Piganelli, Decio Laks Eizirik, Raghavendra G. Mirmira, Emily Kristen Sims
This study shows that beta cell extracellular vesicle PD-L1 increases in type 1 diabetes and inhibits CD8+ T cell activity, correlating with residual beta cell function.
Diabetologia · Nov 7, 2024Peer-reviewedCell Biology