Author

Zhiwei Xu

Indiana University IndianapolisORCID 0000-0002-9278-2083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Emily Kristen SimsiD· 3 shared Raghavendra G. MirmiraiD· 3 shared Ernesto Satoshi NakayasuiD· 2 shared Ivo Díaz LudovicoiD· 2 shared Alan WolfeiD· 1 shared Andre De Oliveira· 1 shared Andre G. De Oliveira· 1 shared Arianna Harris-KawanoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersBiochemistry

Emily Kristen SimsORCID

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3 papers

Recent·Most cited

Carbamylome analysis reveals regulatory roles for lysine carbamylation in β-cell glycolytic and insulin-processing enzymes

Youngki You, Hyeyoon Kim, Mereena George Ushakumary, Marina A. Gritsenko, Hanna E. Walukiewicz, Fangjia Li, Zhiwei Xu, Ivo Díaz Ludovico, Panshak Dakup, Weijun Qian, G C Clair, Gina M. Many, Raghavendra G. Mirmira, Bobbie‐Jo Webb‐Robertson, Alan Wolfe, , Ernesto Satoshi Nakayasu

The paper identifies carbamylation as a regulatory modification in β-cell metabolism and insulin processing in T1D by analyzing proteomic changes in NOD and MIN6 cells.

bioRxiv · May 31, 2026 · PreprintBiochemistry

Proinflammatory stress activates neutral sphingomyelinase 2 based generation of a ceramide-enriched β cell EV subpopulation

Zhiwei Xu, Irene Amalaraj, Andre De Oliveira, Arianna Harris-Kawano, Jacob R. Enriquez, Raghavendra G. Mirmira, Josie Eder, Meagan Burnet, Ivo Díaz Ludovico, Javier E. Flores, Ernesto Satoshi Nakayasu, Emily Kristen Sims

This study shows that proinflammatory stress in beta cells increases ceramide-enriched extracellular vesicles via nSMase2, which may affect paracrine signaling in diabetes.

Diabetes · Sep 2, 2025Peer-reviewedMolecular Biology

Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes

Chaitra Rao, Daniel T. Cater, Saptarshi Roy, Zhiwei Xu, Andre G. De Oliveira, Carmella Evans‐Molina, Jon D. Piganelli, Decio Laks Eizirik, Raghavendra G. Mirmira, Emily Kristen Sims

This study shows that beta cell extracellular vesicle PD-L1 increases in type 1 diabetes and inhibits CD8+ T cell activity, correlating with residual beta cell function.

Diabetologia · Nov 7, 2024Peer-reviewedCell Biology