IgM hyposialylation drives podocyte injury in pediatric and young adult patients with podocytopathies.
Sonia Spinelli, Andrea Garbarino, Francesca Lugani, Edoardo La Porta, Andrea Petretto, Martina Bartolucci, Chiara Lavarello, Nicole Grinovero, Sofia Gaudiano, Ilaria Musante, Paolo Scudieri, Antonella Trivelli, Giorgio Piaggio, Alberto Magnasco, Maria Ludovica Degl’Innocenti, , Maurizio Bruschi
This study shows that reduced sialylation of IgM in patients with podocytopathies correlates with disease activity and causes podocyte injury through oxidative stress and metabolic dysfunction.
bioRxiv · Nov 4, 2025 · PreprintPathology