PathologybioRxivPreprint
IgM hyposialylation drives podocyte injury in pediatric and young adult patients with podocytopathies.
Sonia Spinelli, Andrea Garbarino, Francesca Lugani…·Maurizio Bruschi
This study shows that reduced sialylation of IgM in patients with podocytopathies correlates with disease activity and causes podocyte injury through oxidative stress and metabolic dysfunction.
DOI 10.1101/2025.11.04.686538