This study shows that reduced sialylation of IgM in patients with podocytopathies correlates with disease activity and causes podocyte injury through oxidative stress and metabolic dysfunction.

bioRxiv · Nov 4, 2025 · PreprintPathology

Exome-wide analysis of congenital kidney anomalies reveals new genes and shared architecture with developmental disorders

Hila Milo Rasouly, Sarath Babu Krishna Murthy, Natalie Vena, Gundula Povysil, Andrew Beenken, Miguel Verbitsky, Shirlee Shril, Iris Lekkerkerker, Sandy Yu-Rung Yang, Atlas Khan, David A. Fasel, Janewit Wongboonsin, Jeremiah Martino, Juntao Ke, Naama Elefant, , Yaşar Çalışkan

This study identifies new genes and shared genetic architecture between kidney anomalies and other developmental disorders using exome-wide analysis of clinical cohorts.

Nature Communications · Aug 7, 2025Peer-reviewedGenetic & Genomic Medicine

GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy

Krzysztof Kiryluk, Elena Sánchez, Shu‐Feng Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasà, Jun Y. Zhang, Olivia Balderes, Simone Sanna‐Cherchi, Andrew S. Bomback, Pietro A. Canetta, Gerald B. Appel, Jai Radhakrishnan, , Claudia Izzi

This study identifies 30 genome-wide significant risk loci for IgA nephropathy, links them to inflammatory pathways, and prioritizes drug targets.

medRxiv · Nov 19, 2021 · PreprintGenetic & Genomic Medicine