The Fc fragment of soluble IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement-dependent cytotoxicity
Andrea J. Pinto, Anne Chouquet, Isabelle Bally, Véronique Rossi, Nicole M. Thielens, Chantal Dumestre‐Pérard, Renate Kunert, Christine Gaboriaud, W. L. W. Ling, Jean‐Baptiste Reiser
This study investigates the binding of IgM Fc fragments to C1q and their role in complement activation and inhibition of cytotoxicity.
FEBS Journal · Nov 2, 2025Peer-reviewedBiochemistry