eIF3d drives cholesterol biosynthesis required for KSHV lytic replication
Eric S. Pringle, Carolyn-Ann Robinson, Brett A. Duguay, Christopher S. Hughes, Nicolas Crapoulet, Andrea L.-A. Monjo, Alexa Wilson, Katrina Bouzanis, Andrew M. Leidal, Stephen M. Lewis, Daniel Gaston, James Uniacke, Craig McCormick
This study identifies eIF3d as essential for cholesterol biosynthesis required for KSHV lytic replication, showing its role in supporting translation of cholesterol-related host mRNAs.
bioRxiv · Jul 2, 2026 · PreprintMicrobiology