Christopher S. Hughes

Extracellular flux analysis and proteomic profiling indicate ibogaine promotes synaptic plasticity and neural repair by a metabolic preconditioning mechanism

This study shows ibogaine induces metabolic preconditioning in neurons, enhancing synaptic plasticity and neural repair through transient metabolic stress and sigma-2 receptor activation.

eIF3d drives cholesterol biosynthesis required for KSHV lytic replication

This study identifies eIF3d as essential for cholesterol biosynthesis required for KSHV lytic replication, showing its role in supporting translation of cholesterol-related host mRNAs.

CLM296: a highly selective inhibitor targeting ALDH1A3-driven tumor growth and metastasis in breast cancer

This paper introduces CLM296, a highly selective ALDH1A3 inhibitor that reduces tumor growth and metastasis in TNBC xenografts with favorable pharmacokinetics and safety profile.

Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

RawTools: Rapid and Dynamic Interrogation of Orbitrap Data Files for Mass Spectrometer System Management

RawTools extracts and analyzes data from Thermo Orbitrap raw files to aid in mass spectrometer system management and performance optimization.