A consensus set of genetic vulnerabilities to ATR inhibition
Nicole Hustedt, Alejandro Álvarez-Quilón, Andrea McEwan, Jing Yi Yuan, Tiffany Cho, Lisa Koob, Traver Hart, Daniel Durocher
The paper identifies a consensus set of 117 genes that promote survival when ATR kinase activity is suppressed, validated through CRISPR/Cas9 screens and including previously unknown modulators of ATR inhibitor response.
Open Biology · Sep 1, 2019Peer-reviewedMolecular Biology