Author

Nicole Hustedt

Mount Sinai HospitalORCID 0000-0002-7529-5769Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Daniel DurocheriD· 3 shared Traver HartiD· 2 shared Alejandro Álvarez-QuilóniD· 1 shared Alexander van OudenaardeniD· 1 shared Alexander Weiss· 1 shared Amy H.Y. TongiD· 1 shared Andrea Habsid· 1 shared Andrea McEwan· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

Daniel DurocherORCID

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Author profile →

3 papers

Recent·Most cited

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response

Rinskje B. Tjeerdsma, Timothy F. Ng, Maurits Roorda, Daniëlle Bianchi, Sora Yang, Clara Bonnet, Michael A. VanInsberghe, Marieke Everts, Femke J. Bakker, H. Rudolf de Boer, Nathalie Moatti, Nicole Hustedt, Jay Z. Yin, Lisa Hoeg, Matthew Leibovitch, , Marcel A.T.M. van Vugt

This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.

Nature Communications · Nov 24, 2025Peer-reviewedCancer Biology

A consensus set of genetic vulnerabilities to ATR inhibition

Nicole Hustedt, Alejandro Álvarez-Quilón, Andrea McEwan, Jing Yi Yuan, Tiffany Cho, Lisa Koob, Traver Hart, Daniel Durocher

The paper identifies a consensus set of 117 genes that promote survival when ATR kinase activity is suppressed, validated through CRISPR/Cas9 screens and including previously unknown modulators of ATR inhibitor response.

Open Biology · Sep 1, 2019Peer-reviewedMolecular Biology

Evaluation and Design of Genome-wide CRISPR/Cas9 Knockout Screens

Traver Hart, Amy H.Y. Tong, Katie Chan, Jolanda S. van Leeuwen, Ashwin Seetharaman, Michael Aregger, Megha Chandrashekhar, Nicole Hustedt, Sahil Seth, Avery J. C. Noonan, Andrea Habsid, Olga S. Sizova, Lyudmila Nedyalkova, Ryan Climie, Keith A. Lawson, , Jason Moffat

The paper evaluates CRISPR/Cas9 knockout screens in human cell lines and designs an optimized gRNA library to improve gene knockout efficiency and accuracy.

bioRxiv · Mar 16, 2017 · PreprintSystems Biology