Author

Lisa Koob

Mount Sinai Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Alejandro Álvarez-QuilóniD· 1 shared Alex Watterson· 1 shared Amalie E. Dick· 1 shared Andrea McEwan· 1 shared Anoek FriskesiD· 1 shared Barbara Abreu· 1 shared Benjamin D. RowlandiD· 1 shared Benoît BaillifiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMolecular Biology

Alejandro Álvarez-QuilónORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure-function analysis of PI3K signalling cascade base editing screens in cancer cells

Katrina McCarten, Barbara Abreu, Benoît Baillif, Lisa Koob, Jong Sook Ahn, Cansu Dinçer, Julian Esselborn, Emre Karakoç, R. Frederick Ludlow, John F. Lyons, Gabriele Picco, Mamta Sharma, Marcel L. Verdonk, Mark R. Wade, Samantha J. Walker, , Mathew J. Garnett

The paper uses CRISPR base editing and structural analysis to identify functional residues in the PI3K pathway, revealing potential drug targets and allosteric pockets.

bioRxiv · Sep 14, 2026 · PreprintGenomics

Visualizing homology search in living cells

Anoek Friskes, Melanie Snoek, Lisa Koob, Roel Oldenkamp, Bram van den Broek, Leila Nahidiazar, Lukas Frank, Amalie E. Dick, Marjolijn Mertz, Rolf Harkes, Benjamin D. Rowland, Kees Jalink, René H. Medema

This study visualizes homology search dynamics in living human cells using GFP-MND1, revealing filament structures that resolve over time and depend on RAD54L and cohesin.

Nucleic Acids Research · Aug 25, 2026Peer-reviewedCell Biology

A consensus set of genetic vulnerabilities to ATR inhibition

Nicole Hustedt, Alejandro Álvarez-Quilón, Andrea McEwan, Jing Yi Yuan, Tiffany Cho, Lisa Koob, Traver Hart, Daniel Durocher

The paper identifies a consensus set of 117 genes that promote survival when ATR kinase activity is suppressed, validated through CRISPR/Cas9 screens and including previously unknown modulators of ATR inhibitor response.

Open Biology · Sep 1, 2019Peer-reviewedMolecular Biology