Generative AI Guided Design of High-Affinity T cell Receptors
Martin Renqiang Min, Tianxiao Li, Kazuhide Onoguchi, Daiki Mori, Ayako Demachi‐Okamura, Jonathan Warrell, Pierre Machart, Anja Mösch, Andrea Meiser, Ivy Grace Pait, Daisuke Muraoka, Hirokazu Matsushita, Giulia Paiardi, Matheus Ferraz, Kaïdre Bendjama
This paper introduces TCRPPO2, an AI-driven framework for optimizing TCR affinity, showing improved activity in engineered TCRs against tumor antigens.
bioRxiv · Feb 18, 2026 · PreprintImmunology