Giulia Paiardi

This paper introduces TCRPPO2, an AI-driven framework for optimizing TCR affinity, showing improved activity in engineered TCRs against tumor antigens.

This study shows K5 polysaccharides inhibit SARS-CoV-2 by blocking spike binding to ACE2 and furin cleavage, with K5OSH showing stronger antiviral activity than heparin.

This paper uses molecular dynamics simulations to show that heparan sulfate and N-glycans stabilize the SARS-CoV-2 spike:ACE2 complex and promote viral entry by triggering structural changes.