Essential Role for Trf2 in Cardiac Development and Function
Ali Hakim Shoushtari, Aysenur Danis, Michael Wayne Stoner, Jeffrey Baust, Andrea Sebastiani, Paramesha Bugga, Janet R. Manning, Bellina A.S. Mushala, Nisha Bhattarai, Imad Al Ghouleh, Iain Scott, Maryam Sharifi‐Sanjani
This study shows that Trf2 is critical for cardiac development and function, with CM-specific loss causing heart morphology defects and cardiac dysfunction without telomere shortening.
bioRxiv · Sep 24, 2025 · PreprintDevelopmental Biology