Nisha Bhattarai

This study uses coarse-grained simulations to show how TM and TM-proximal domains of EphA1 and EphA2 differ in dimerization and lipid interactions, explaining their distinct activation behaviors.

The paper examines the mRNA abundance of RIDD target genes in heart failure patients and mice, finding decreased expression consistent with RIDD activation.

This study uses molecular dynamics simulations to investigate how PIP2/3 and Rnd1 affect Plexin-B1 GAP activity on Rap1b GTPase, revealing lipid-dependent structural and functional changes.

This study shows that Trf2 is critical for cardiac development and function, with CM-specific loss causing heart morphology defects and cardiac dysfunction without telomere shortening.

This study shows that GCN5L1 loss increases pyruvate dehydrogenase phosphorylation, inhibiting glucose oxidation and worsening myocardial damage during ischemia-reperfusion injury.

This study shows Adropin treatment reverses cardiac dysfunction and metabolic defects in a mouse model of HFpEF by reducing O-GlcNAcylation of LCAD and improving fatty acid oxidation.

The paper uses molecular dynamics simulations to analyze conformational changes in Plexin-B1 bound to Rap1b, Rnd1, and Rac1, revealing differences in dynamics and interactions.

This study identifies Gcn5l1 as a heart-specific factor that modulates cholesterol metabolism and heart-to-liver crosstalk in cardiometabolic heart failure, revealing the heart's role in systemic metabolic dysfunction.

This study uses simulations to show cholesterol stabilizes EphA2 dimerization and TM-JM interactions with PIP2, highlighting membrane composition's role in EphA2 signaling and cancer progression.

This study shows that TCA cycle dysfunction and amino acid catabolism in mice with HFpEF drive hepatic steatosis similar to human NAFLD.

The paper uses molecular dynamics simulations to analyze four SCN2A variants, revealing how they affect channel structure and function, with R937C being the most unstable.

This study identifies somatic and germline genetic variants in 474 epileptogenic brain lesions, revealing associations with specific epilepsy subtypes and informing clinical genetic screening.