Author

Bellina A.S. Mushala

University of PittsburghORCID 0000-0002-5694-7573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Assay:metabolomics· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Iain ScottiD· 5 shared Janet R. ManningiD· 5 shared Maryam Sharifi‐Sanjani· 5 shared Michael Wayne StoneriD· 5 shared Nisha BhattaraiiD· 5 shared Paramesha BuggaiD· 5 shared Amber M. VandevenderiD· 3 shared Brett A. KaufmaniD· 3 shared

Activity by Year

2024-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersPhysiology

Iain ScottORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Essential Role for Trf2 in Cardiac Development and Function

Ali Hakim Shoushtari, Aysenur Danis, Michael Wayne Stoner, Jeffrey Baust, Andrea Sebastiani, Paramesha Bugga, Janet R. Manning, Bellina A.S. Mushala, Nisha Bhattarai, Imad Al Ghouleh, Iain Scott, Maryam Sharifi‐Sanjani

This study shows that Trf2 is critical for cardiac development and function, with CM-specific loss causing heart morphology defects and cardiac dysfunction without telomere shortening.

bioRxiv · Sep 24, 2025 · PreprintDevelopmental Biology

GCN5L1 inhibits pyruvate dehydrogenase phosphorylation during cardiac ischemia- reperfusion injury

Paramesha Bugga, Michael Wayne Stoner, Janet R. Manning, Bellina A.S. Mushala, Nisha Bhattarai, Maryam Sharifi‐Sanjani, Iain Scott

This study shows that GCN5L1 loss increases pyruvate dehydrogenase phosphorylation, inhibiting glucose oxidation and worsening myocardial damage during ischemia-reperfusion injury.

FASEB BioAdvances · Sep 1, 2025Peer-reviewedPhysiology

Adropin protects against cardiac remodeling and metabolic dysfunction in a mouse model of HFpEF

Bellina A.S. Mushala, Michael Wayne Stoner, Maryam Sharifi‐Sanjani, Janet R. Manning, Paramesha Bugga, Nisha Bhattarai, Brenda McMahon, Amber M. Vandevender, Steven J. Mullett, Brett A. Kaufman, Sruti S. Shiva, Cheng Zhang, Eric S. Goetzman, Stephen Y. Chan, Stacy L. Gelhaus, , Iain Scott

This study shows Adropin treatment reverses cardiac dysfunction and metabolic defects in a mouse model of HFpEF by reducing O-GlcNAcylation of LCAD and improving fatty acid oxidation.

bioRxiv · May 3, 2025 · PreprintPhysiology

Gcn5l1 governs heart-to-liver crosstalk in cardiometabolic heart failure by modulating cholesterol metabolism

Paramesha Bugga, Bellina A.S. Mushala, Michael Wayne Stoner, Janet R. Manning, Nisha Bhattarai, Maryam Sharifi‐Sanjani, Manling Zhang, Amber M. Vandevender, Raja Gopal Reddy Mooli, Sadeesh K. Ramakrishnan, John Sembrat, Brett A. Kaufman, Sruti S Shiva, Cassandra L. Happe, Steven J. Mullett, , Iain Scott

This study identifies Gcn5l1 as a heart-specific factor that modulates cholesterol metabolism and heart-to-liver crosstalk in cardiometabolic heart failure, revealing the heart's role in systemic metabolic dysfunction.

bioRxiv · Feb 5, 2025 · PreprintPhysiology

TCA Cycle Dysfunction and Amino Acid Catabolism Drive Hepatic Steatosis in Mice with HFpEF

Bellina A.S. Mushala, Michael Wayne Stoner, Janet R. Manning, Paramesha Bugga, Nisha Bhattarai, Maryam Sharifi‐Sanjani, Brenda McMahon, Amber M. Vandevender, Steven J. Mullett, Brett A. Kaufman, Sruti S. Shiva, Stacy L. Gelhaus, Michael J. Jurczak, Iain Scott

This study shows that TCA cycle dysfunction and amino acid catabolism in mice with HFpEF drive hepatic steatosis similar to human NAFLD.

bioRxiv · Jun 3, 2024 · PreprintPhysiology