The Legionella phosphocholinase AnkX modulates IMPDH2 regulation and cytoophidia dynamics
Pia Stauffer, Marietta S. Kaspers, Anna Leoni Swart, Philipp Ochtrop, Bente Siebels, Vivian Pogenberg, Daniel Ferreiro Otero, Andreas Brockmeyer, Camille Schmid, Petra Janning, Hartmut Schlüter, Christian Hedberg, Aymelt Itzen, Hubert Hilbi
This paper identifies AnkX as a Legionella effector that posttranslationally modifies IMPDH2, disrupting its filament assembly and altering GTP metabolism in host cells.
bioRxiv · Feb 10, 2026 · PreprintMicrobiology