Hubert Hilbi

Time-resolved transcriptomic profiling of Dictyostelium discoideum infection with Mycobacterium marinum reveals Atg9-dependent restriction via maintenance of vacuole integrity

This study uses Dictyostelium discoideum to investigate host responses to Mycobacterium marinum infection, identifying Atg9's role in maintaining vacuole integrity and restricting bacterial growth.

The Legionella effector RidL promotes mitochondrial fragmentation through phosphorylation activation of the large GTPase Drp1

This study identifies RidL as a bifunctional effector that inhibits retrograde trafficking and promotes mitochondrial fragmentation by phosphorylating Drp1, aiding Legionella pneumophila's intracellular survival.

PDIM drives the transition from repairable to catastrophic EsxA-mediated vacuole membrane damage during Mycobacterium marinum infection

This study shows that EsxA initiates MCV membrane damage while PDIM amplifies lesions to cause catastrophic rupture, enabling bacterial escape.

Intracellular compartmentalization shapes lipid access and metabolic fitness of mycobacteria

The paper shows that lipid metabolism in mycobacteria is linked to their subcellular location, with FACL6 deletion disrupting lipid handling and reducing intracellular fitness.

The Legionella phosphocholinase AnkX modulates IMPDH2 regulation and cytoophidia dynamics

This paper identifies AnkX as a Legionella effector that posttranslationally modifies IMPDH2, disrupting its filament assembly and altering GTP metabolism in host cells.

Inter-kingdom signaling by the Legionella autoinducer LAI-1 involves the antimicrobial guanylate binding protein GBP

This study shows LAI-1, a signaling molecule from Legionella pneumophila, interacts with GBP in D. discoideum to inhibit migration and restrict bacterial growth.

Time-resolved RNA-seq profiling of the infection of Dictyostelium discoideum by Mycobacterium marinum reveals an integrated host response to damage and stress

This study uses time-resolved RNA-seq to analyze D. discoideum gene expression during M. marinum infection, identifying key pathways involved in host response to damage, stress, and metabolic adaptation.