Author

Petra Janning

Max Planck Institute of Molecular Physiology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:chromatin & epigenetic regulation· 5 Organism:human· 5 Research Focus:protein folding & dynamics· 4 Approach:biophysical modeling· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:proteomics· 3

Frequent Co-Authors

Ingrid R. VetteriD· 3 shared Andrea MusacchioiD· 2 shared Franziska MülleriD· 2 shared Raphael GasperiD· 2 shared Alexandra Brause· 1 shared Amrita RaiiD· 1 shared Andreas Brockmeyer· 1 shared Anna Leoni SwartiD· 1 shared

Activity by Year

2024-2026 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

Ingrid R. VetterORCID

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Author profile →

7 papers

Recent·Most cited

Assembly principles of a SYCP2-HORMAD1-HORMAD2 mammalian meiotic axis complex

E. S. Selezneva, Franziska Müller, Petra Janning, John R. Weir

This study identifies a new closure motif in SYCP2 and shows how HORMAD1 and HORMAD2 form a heterodimer, revising the model of mammalian meiotic axis assembly.

bioRxiv · Jun 8, 2026 · PreprintCell Biology

Molecular anatomy of PLK1 master docking motifs

Long Ren, Arianna Esposito-Verza, Raphael Gasper, Marion E. Pesenti, Petra Janning, Franziska Müller, Carolin Koerner, Petra Geue, Sabine Wohlgemuth, Ingrid R. Vetter, Andrea Musacchio

The paper identifies a high-affinity master docking motif on CENP-U that interacts extensively with PLK1's Polo-box domain, suggesting common features among master PLK1 docking motifs.

Nature Communications · May 11, 2026Peer-reviewedBiochemistry

The Legionella phosphocholinase AnkX modulates IMPDH2 regulation and cytoophidia dynamics

Pia Stauffer, Marietta S. Kaspers, Anna Leoni Swart, Philipp Ochtrop, Bente Siebels, Vivian Pogenberg, Daniel Ferreiro Otero, Andreas Brockmeyer, Camille Schmid, Petra Janning, Hartmut Schlüter, Christian Hedberg, Aymelt Itzen, Hubert Hilbi

This paper identifies AnkX as a Legionella effector that posttranslationally modifies IMPDH2, disrupting its filament assembly and altering GTP metabolism in host cells.

bioRxiv · Feb 10, 2026 · PreprintMicrobiology

M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans

Kai Walstein, Louisa Hill, Doro Vogt, Lina Oberste-Lehn, Petra Janning, Ingrid R. Vetter, Dongqing Pan, Andrea Musacchio

The paper identifies M18BP1 dimerization and its interaction determinants as key for centromere specification through epigenetic mechanisms in humans.

The EMBO Journal · Feb 2, 2026Peer-reviewedCell Biology

Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3

Elisabeth Hennes, Belén Lucas, Natalie S. Scholes, Xiu‐Fen Cheng, Daniel C. Scott, Matthias Bischoff, Katharina Reich, Raphael Gasper, María Lucas, Teng Teng Xu, Sofia Rossini, Lisa‐Marie Pulvermacher, Lara Dötsch, Hana Imrichová, Alexandra Brause, , Herbert Waldmann

The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.

Nature Chemistry · Jan 7, 2026Peer-reviewedCell Biology

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand-Symmetric and -Asymmetric 5-Hydroxymethylcytosine-Modifications in DNA

Lena Engelhard, Zeyneb Vildan Cakil, Marlon Steven Zambrano-Mila, Simone Eppmann, Tye I. Gonzalez, Rasmus Linser, Petra Janning, Sidney M. Becker, Daniel Summerer

The paper identifies tissue-specific readers and antireaders of symmetric and asymmetric hmC modifications in DNA using proteomics and promoter probe assays in human and mouse cells.

Advanced Science · Jan 4, 2026Peer-reviewedBiochemistry

Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8

Amrita Rai, Petra Janning, Ingrid R. Vetter, Roger Sidney Goody

This study characterizes the auto-inhibited state of Mical1 and shows how Rab8 binding releases inhibition through structural and biochemical analysis.

bioRxiv · Jun 17, 2024 · PreprintBiochemistry