A dynamic activation-memory cycle organizes the human IgG⁺ memory B cell compartment
Laura T. M. Graus, Andreas Chrysostomou, Denise Guerra, Gius Kerster, Karlijn van der Straten, Jacqueline van Rijswijk, Khadija Tejjani, Tim Beaumont, Maria Prins, Menno D. de Jong, Godelieve J. de Bree, Rogier W. Sanders, Marit J. van Gils, Mathieu A. F. Claireaux
This study defines the dynamic activation-memory cycle of human IgG memory B cells through single-cell profiling, revealing distinct reactivation trajectories and functional roles in humoral immunity.
bioRxiv · Oct 30, 2025 · PreprintImmunology