Godelieve J. de Bree

Sequential vaccination matures VRC01-class HIV-1 neutralizing antibodies in humans

This study shows that sequential vaccination can mature VRC01-class B cells into antibodies that neutralize a broad range of HIV-1 viruses.

Adjuvants MPLA and SMNP induce antiviral immunity and indirectly revert HIV-1 latency

This study shows that SMNP, a TLR4-targeted adjuvant, induces stronger immune activation and reduces HIV-1 reservoir size in PWH ex vivo compared to MPLA.

Direct serological antibody discovery by integrative proteomics yields potent neutralizers overlooked by single-cell BCR sequencing

The paper introduces AbDirect, a proteomics-based method for antibody discovery that identifies potent neutralizing antibodies missed by single-cell BCR sequencing in COVID-19 plasma.

A dynamic activation-memory cycle organizes the human IgG⁺ memory B cell compartment

This study defines the dynamic activation-memory cycle of human IgG memory B cells through single-cell profiling, revealing distinct reactivation trajectories and functional roles in humoral immunity.

HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation predicts the subsequent reduction of the viral reservoir