Dynamic CTCF bridges drive genome organization
Colleen C. Caldwell, Matilde Sá, Bram J. Hoogland, Andrea Ridolfi, Natal F. Zaghal, Chase P. Broedersz, Andreas S. Biebricher, Gijs J. L. Wuite
The paper shows CTCF forms dynamic DNA bridges that stabilize chromatin loops independently of cohesin, challenging the loop extrusion model.
bioRxiv · May 2, 2026 · PreprintBiophysics