Chase P. Broedersz

This study uses optical tweezers to measure the mechanical properties of human centromeres, revealing stiffness at low forces and softening under tension, with implications for chromosome segregation.

The paper shows CTCF forms dynamic DNA bridges that stabilize chromatin loops independently of cohesin, challenging the loop extrusion model.

This study uses AFM to analyze the structure and micromechanics of mitotic chromosomes, revealing fractal properties and elastic recovery behavior.

The paper develops a 4D Maximum Entropy model to analyze time-course Hi-C data and reveals dynamic chromosome organization in Caulobacter crescentus during replication.

This paper constructs a biophysical model showing how loop extrusion by MukBEF and exclusion by MatP can establish left-ori-right chromosome order in E. coli without locus anchoring.

This study shows MDA5 compacts dsRNA via ATP-dependent loop extrusion, stabilizing the structure through CARD domain oligomerization.