Gijs J. L. Wuite

Mechanical characterization of human centromeres

This study uses optical tweezers to measure the mechanical properties of human centromeres, revealing stiffness at low forces and softening under tension, with implications for chromosome segregation.

Dynamic CTCF bridges drive genome organization

The paper shows CTCF forms dynamic DNA bridges that stabilize chromatin loops independently of cohesin, challenging the loop extrusion model.

Resolving interface structure and local internal mechanics of mitotic chromosomes

This study uses AFM to analyze the structure and micromechanics of mitotic chromosomes, revealing fractal properties and elastic recovery behavior.

DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins

This study investigates how DNA polymerase displaces SSBs during replication, showing sequential displacement and the role of SSB saturation in replication efficiency.

Condensin I confers Stiffness and Centromeric Cohesion to Mitotic Chromosomes

This study investigates the role of Condensin I in establishing and maintaining mitotic chromosome stiffness and centromeric cohesion through mechanical analysis and live cell imaging.

Metabolically intact nuclei are fluidized by the activity of the chromatin remodeling motor BRG1

This study shows that BRG1 activity fluidizes the nucleus, altering its stiffness and dissipating mechanical energy, with implications for nuclear mechanics and remodeling.